Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Frontiers in Medicine

article

Dominic Stanculescu¹  Lars Larsson²  Jonas Bergquist³ 

[1] Independent Researcher;Basic and Clinical Muscle Biology, Department of Physiology and Pharmacology, Karolinska Institute;Department of Chemistry – Biomedical Center, Uppsala University;The Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centre at Uppsala University

关键词: myalgic encephalomyelitis;    critical illness;    non-thyroidal illness syndrome;    low t-3 syndrome;    pituitary;    cytokines;    oxidative and nitrosative stress;    post-intensive care syndrome;   

DOI  :  10.3389/fmed.2021.628029

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression of the pituitary gland's pulsatile secretion of tropic hormones, and (b) a “vicious circle” between inflammation, oxidative and nitrosative stress (O&NS), and low thyroid hormone function . This hypothesis should be investigated through collaborative research projects.

【 授权许可】

CC BY