Editorial: Antithrombotic Prophylaxis in Patients With Atrial Fibrillation for Stroke Prevention: Evidence From Randomized Clinical Trials, Observational Studies, Methodological Modeling, and More

Frontiers in Medicine

article

Junguo Zhang¹  Lehana Thabane²  Ziyi Li¹  Guowei Li¹ 

[1] Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital;Department of Health Research Methods, McMaster University

关键词: antithrombotic prophylaxis;    stroke prevention;    atrial fibrillation;    direct oral anticoagulants;    treatment;   

DOI  :  10.3389/fmed.2021.658303

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Atrial fibrillation (AF) as the most common sustained cardiac arrhythmia, is associated with a 5-fold increase in stroke risk. Use of anticoagulants remains the mainstay to prevent AF-related strokes (1). Since 2009, the direct oral anticoagulants (DOACs), including direct thrombin inhibitor (dabigatran) and factor Xa inhibitors (apixaban, rivaroxaban, and edoxaban), were developed to replace vitamin K antagonists (VKA) for patients with AF, mainly owing to their predictable and favorable pharmacological profiles (2). Nevertheless, with evolving knowledge landscape, obtaining or determining optimal information or best available evidence to guide clinical decisionmaking for the use of anticoagulants remains a challenge. This special issue has been dedicated to disseminating new insights on the antithrombotic prophylaxis in patients with AF for stroke prevention. Articles outlined below illustrate the most up-to-date evidence of antithrombotic prophylaxis and stroke prevention, which involves several topics to help with clinical practice and patient management including stroke and bleeding risk assessments, the use of DOACs in older individuals, indirect comparison among DOACs in patients with venous thromboembolism (VTE), minimally interrupted DOAC for AF ablation and antithrombotic treatment strategies in patients with AF undergoing elective percutaneous coronary intervention (PCI).

【 授权许可】

CC BY