Neonatal Lung Diseases: A Clinical Potential for Sex Steroids and a Novel Intracrine Organ

Frontiers in Medicine

article

Yves Tremblay¹  Alexia Morin-Labbé¹ 

[1] Perinatal and Child Health;Department of Obstetric, Faculty of Medicine, Laval University;Centre de Recherche en Reproduction, Laval University

关键词: neonatal;    lung;    steroid;    intracrinology;    sex steroid;    androgen;   

DOI  :  10.3389/fmed.2021.664969

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Intracrinology refers to the production of active sex steroids in situ within the cells where the action takes place. The active hormones are not released in the extracellular space (1, 2) as opposed to endocrinology where glands release active hormones in circulation to exert their effect on target tissues. The term “intracrinology” has been coined 30 years ago during the study of the prostate (3). It has been shown that after removing androgens of testicular origin, the prostate still produces dihydrotestosterone (DHT) from an inactive circulating sex steroid precursor of adrenal origin. Can this concept of intracrinology be extended to the developing lung?.

【 授权许可】

CC BY