期刊论文详细信息
Frontiers in Medicine
Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?
article
Ying Tan1  Yan Qin1  Xiao-juan Yu1  Rong Xu1  Su-xia Wang1  Fu-de Zhou1  Ming-hui Zhao1 
[1] Renal Division, Department of Medicine, Peking University First Hospital;Institute of Nephrology, Peking University;Key Laboratory of Renal Disease, Ministry of Health of China;Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China;Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences;The Second People's Hospital of Shanxi Province;Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital;Peking-Tsinghua Center for Life Sciences
关键词: systemic lupus erythematosus;    lupus nephritis;    predominant interstitial nephritis;    IgG3;    storiform pattern;   
DOI  :  10.3389/fmed.2021.684889
学科分类:社会科学、人文和艺术(综合)
来源: Frontiers
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【 摘 要 】

Isolated or dominant tubulointerstitial lupus nephritis is rare. Here, we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past 2 years. Renal biopsy showed almost normal glomeruli, but the tubulointerstitium showed “storiform” pattern with interstitial infiltration of IgG3 predominant plasma cells. Immunofluorescence showed linear and granular staining of IgG and C1q along TBM and interstitium. He started on medium dose of oral steroids and mycophenolate mofetil, which were gradually tapered. As a result, his renal function improved over a few days. Now, he continued on low dose steroids and mycophenolate mofetil with no evidence of relapse.

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