期刊论文详细信息
Frontiers in Medicine
Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome
article
Alessandra G. D. Lopes1  Ana C. E. Z. Santos1  Luis A. Divan1  Ingrid A. B. Alves1  Danielle B. L. Oliveira2  Rafael R. G. Machado2  Luciano M. Thomazelli2  Meire I. Hiyane4  Leonília Brelaz-Abreu5  Elayne Bragança-Jardim5  Letícia B. S. Heinen5  Camila S. H. Celestino1  Anna C. M. Barrientos1  Luciana B. Mau1  Niels O. S. Camara4  Daniela F. Bueno1  Mariane T. Amano5  Tiago T. A. Barros1  Aline G. Fevereiro1  Debora H. Gejer1  Fernando M. F. Oliveira1  Jamile M. Brasil1  Rosely M. Bossolan1  Gabriela C. C. Pinto1 
[1] Hospital Municipal Infantil Menino Jesus;Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo;Hospital Israelita Albert Einstein;Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo;Hospital Sírio-Libanês
关键词: COVID19;    SARS-CoV-2;    Angelman syndrome;    neutralizing antibodies;    intensive care unit;    inflammation;    immune response;   
DOI  :  10.3389/fmed.2021.629112
学科分类:社会科学、人文和艺术(综合)
来源: Frontiers
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【 摘 要 】

Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.

【 授权许可】

CC BY   

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