Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome

Frontiers in Medicine

article

Alessandra G. D. Lopes¹  Ana C. E. Z. Santos¹  Luis A. Divan¹  Ingrid A. B. Alves¹  Danielle B. L. Oliveira²  Rafael R. G. Machado²  Luciano M. Thomazelli²  Meire I. Hiyane⁴  Leonília Brelaz-Abreu⁵  Elayne Bragança-Jardim⁵  Letícia B. S. Heinen⁵  Camila S. H. Celestino¹  Anna C. M. Barrientos¹  Luciana B. Mau¹  Niels O. S. Camara⁴  Daniela F. Bueno¹  Mariane T. Amano⁵  Tiago T. A. Barros¹  Aline G. Fevereiro¹  Debora H. Gejer¹  Fernando M. F. Oliveira¹  Jamile M. Brasil¹  Rosely M. Bossolan¹  Gabriela C. C. Pinto¹ 

[1] Hospital Municipal Infantil Menino Jesus;Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo;Hospital Israelita Albert Einstein;Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo;Hospital Sírio-Libanês

关键词: COVID19;    SARS-CoV-2;    Angelman syndrome;    neutralizing antibodies;    intensive care unit;    inflammation;    immune response;   

DOI  :  10.3389/fmed.2021.629112

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.

【 授权许可】

CC BY