Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis

Frontiers in Medicine

article

Marcus Kiiti Borges¹  Marco Canevelli²  Matteo Cesari³  Ivan Aprahamian¹ 

[1] Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo;Department of Human Neuroscience, Sapienza University;University of Milan;Geriatrics and Psychiatry Division, Department of Internal Medicine, Faculty of Medicine of Jundiaí

关键词: mild cognitive impairment;    cognitive decline;    dementia;    cognitive disorders;    comorbidity;    elderly;    meta-analysis;   

DOI  :  10.3389/fmed.2019.00026

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background/Aim: Current evidence in the literature supports associations between frailty, cognitive impairment, and dementia. The study aim was to describe the risk of cognitive disorders associated with physical frailty in older adults from community-based studies. Methods: We performed a systematic review and meta-analysis, using MEDLINE, PsycINFO, Scopus, and Web of Science as databases for the search. Cohort and longitudinal studies were included in qualitative analysis and quantitative synthesis. For inclusion, studies had to assess dementia and cognitive impairment as a primary or secondary outcome, and describe the prevalence of frailty among participants at baseline and follow-up. Results: Of the 2,210 studies retrieved by the systematic review, 6 relevant studies were included in a meta-analysis. Baseline frailty was significantly associated with an increased risk of geriatric cognitive disorders (pooled OR = 1.80, 95% CI = 1.11–2.92; p = 0.02). Heterogeneity across the studies was significant ( I 2 = 79%). Conclusions: The analyses confirmed that frail older adults were at higher risk of incident cognitive disorders than non-frail elders. Frailty status seems to be most associated with the risk of incident dementia. Frailty may represent a risk factor for dementia and could constitute a novel modifiable target in early cognitive impairment.

【 授权许可】

CC BY