Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research

Frontiers in Medicine

article

Cheng Zhong¹  Johanna Schleifenbaum¹ 

[1] Institute of Vegetative Physiology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin

关键词: calcium;    GCaMP;    hypertension;    kidney;    imaging;   

DOI  :  10.3389/fmed.2019.00128

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years. Renovascular disease is one of the most common causes of secondary hypertension. Vascular changes seen in hypertension are partially based on dysfunctional calcium signaling. This signaling can be studied using calcium indicators (loading dyes and genetically encoded calcium indicators; GECIs ). Most progress in development has been seen in GECIs, which are used in an increasing number of publications concerning calcium signaling in vasculature and the kidney. The use of transgenic mouse models expressing GECIs will facilitate new possibilities to study dysfunctional calcium signaling in a cell type-specific manner, thus helping to identify more specific targets for treatment of (renal) hypertension.

【 授权许可】

CC BY