Polyphosphate as a Target for Interference With Inflammation and Thrombosis

Frontiers in Medicine

article

Reiner K. W. Mailer¹  Mikel Allende¹  Thomas Renné¹ 

[1] Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf

关键词: polyphosphate;    factor XII;    hereditary angioedema;    thrombosis;    inflammation;    coagulation;    immune activation;    vascular permeability;   

DOI  :  10.3389/fmed.2019.00076

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.

【 授权许可】

CC BY