Biomarkers for Predicting Efficacies of Anti-PD1 Antibodies

Frontiers in Medicine

article

Yumi Kambayashi¹  Takanori Hidaka¹  Setsuya Aiba¹ 

[1] Department of Dermatology, Tohoku University Graduate School of Medicine

关键词: anti-PD1 antibodies;    routine blood test;    LDH;    MSH;    TMB;    TAM-related factors;   

DOI  :  10.3389/fmed.2019.00174

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Therapeutic options for treating advanced melanoma are progressing rapidly. Although anti-programmed cell death 1 (PD1) antibodies (e.g., nivolumab, pembrolizumab) have been approved as first-line and anchor drugs, respectively, for treating advanced melanoma, the efficacy appears limited as we expected, especially in Asian populations. Biomarkers to predict or evaluate the efficacy of anti-PD1 antibodies are needed to avoid subjecting patients to potentially severe adverse events associated with switching to other anti-melanoma drugs. This review focuses on the recent development of biomarkers for assessing the efficacy of anti-PD1 antibodies using routine blood tests such as the neutrophil-to-lymphocyte ratio, eosinophil ratio, serum markers such as lactate dehydrogenase, programmed cell death ligand 1 (PD-L1) expression on melanoma cells, microsatellite instability and mismatch repair deficiency assays, as well as soluble CD163, and tumor-associated macrophage-related chemokines (e.g., CXCL5, CXCL10).

【 授权许可】

CC BY