Polyphosphates and Complement Activation

Frontiers in Medicine

article

Edward M. Conway¹ 

[1] Division of Hematology, Department of Medicine, Faculty of Medicine, Centre for Blood Research, Life Sciences Institute, University of British Columbia

关键词: innate immunity;    thrombosis;    inflammation;    coagulation;    age-related macular degeneration;    mouse models;    C1-esterase inhibitor;    membrane attack complex;   

DOI  :  10.3389/fmed.2019.00067

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

To sustain life in environments that are fraught with risks of life-threatening injury, organisms have developed innate protective strategies such that the response to wounds is rapid and localized, with the simultaneous recruitment of molecular, biochemical, and cellular pathways that limit bleeding and eliminate pathogens and damaged host cells, while promoting effective healing. These pathways are both coordinated and tightly regulated, as their over- or under-activation may lead to inadequate healing, disease, and/or demise of the host. Recent advances in our understanding of coagulation and complement, a key component of innate immunity, have revealed an intriguing linkage of the two systems. Cell-secreted polyphosphate promotes coagulation, while dampening complement activation, discoveries that are providing insights into disease mechanisms and suggesting novel therapeutic strategies.

【 授权许可】

CC BY