Preoperative Interventions for Alcohol and Other Recreational Substance Use: A Systematic Review and Meta-Analysis

Frontiers in Psychology

article

Luke Budworth¹  Andrew Prestwich¹  Rebecca Lawton¹  Alwyn Kotzé³  Ian Kellar¹ 

[1] School of Psychology, University of Leeds, United Kingdom;Bradford Institute for Health Research, Bradford Royal Infirmary, United Kingdom;Department of Anaesthesia, Leeds Teaching Hospitals NHS Trust, United Kingdom

关键词: alcohol consumption;    illicit drugs;    perioperative care;    postoperative complications;    preoperative period;    substance-related disorder;   

DOI  :  10.3389/fpsyg.2019.00034

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Preoperative alcohol and other recreational substance use (ORSU) may catalyze perioperative complications. Accordingly, interventions aiming to reduce preoperative substance use are warranted. Methods: Studies investigating interventions to reduce alcohol and/or ORSU in elective surgery patients were identified from: Cochrane Library; MEDLINE; PSYCINFO; EMBASE; and CINAHL. In both narrative summaries of results and random effects meta-analyses, effects of interventions on perioperative alcohol/ORSU, complications, mortality and length of stay were assessed. Primary Results: Nine studies ( n = 903) were included. Seven used behavioral interventions only, two provided disulfiram in addition. Pooled analyses found small effects on alcohol use ( d : 0.34; 0.05–0.64), though two trials using disulfiram (0.71; 0.36–1.07) were superior to two using behavioral interventions (0.45; −0.49–1.39). No significant pooled effects were found for perioperative complications, length of hospital stay or mortality in studies solely targeting alcohol/ORSU. Too few interventions targeting ORSU ( n = 1) were located to form conclusions regarding their efficacy. Studies were generally at high risk-of-bias and heterogeneous. Conclusions: Preoperative interventions were beneficial in reducing substance use in some instances, but more high-quality studies targeting alcohol/ORSU specifically are needed. The literature to date does not suggest that such interventions can reduce postoperative morbidity, length of hospital stay or mortality. Limitations in the literature are outlined and recommendations for future studies are suggested.

【 授权许可】

CC BY