The Reason Why rTMS and tDCS Are Efficient in Treatments of Depression

Frontiers in Psychology

article

Milena Čukić¹ 

[1] Department for General Physiology and Biophysics, University of Belgrade;Instituto de Tecnología del Conocimiento, Complutense University of Madrid

关键词: physiological complexity;    rTMS;    tDCS;    depression;    efficiency of treatment;    neuromodulation;   

DOI  :  10.3389/fpsyg.2019.02923

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The exact neurophysiological mechanisms of repetitive transcranial magnetic stimulation (rTMS)and transcranial direct current stimulation (tDCS) for treating patients diagnosed with depressionare still not clear. Results of previous structural and functional MRI studies showed an aberatedfunctional connectivity in major depressive disorder (MDD) (Vederine et al., 2011; de Kwaastenietet al., 2013). Those, as well as several connectivity studies (Bluhm et al., 2009; Berman et al.,2011; Zhang et al., 2011; Kim et al., 2013; Chen et al., 2015) seem to support the hypothesis thataberrant functional connectivity within fronto-limbic system underlies the pathophysiology ofdepression. It should be noted that antidepressant application of both rTMS and tDCS is based onprevious findings that these two methods help in the case of hypoactivity of the left dorsolateralprefrontal cortex (DLPFC) (Grimm et al., 2006). Those structural and functional differencesprobably introduce abnormal physiological complexity demonstrated in electroencephalographic(EEG) (Ahmadlou et al., 2012; Bachmann et al., 2013; Hosseinifard et al., 2014; De la Torre-Luqueand Bornas, 2017; Jaworska et al., 2018; Lebiecka et al., 2018) as well as in electrocardiographic(ECG) signals in depression (Migliorinni et al., 2012; Rossi et al., 2016; Iseger et al., 2019).

【 授权许可】

CC BY