Higher Negative Self-Reference Level in Patients With Personality Disorders and Suicide Attempt(s) History During Biological Treatment for Major Depressive Disorder: Clinical Implications

Frontiers in Psychology

article

Samuel Bulteau¹  Morgane Péré³  Myriam Blanchin¹  Emmanuel Poulet⁴  Jérôme Brunelin⁴  Anne Sauvaget⁶  Véronique Sébille¹ 

[1] SPHERE MethodS in Patient-Centered Outcomes and HEalth ResEarch, University of Nantes, University of Tours;Department of Addictology and Psychiatry;Department of Methodology and Biostatistics;Lyon Neuroscience Research Center, University of Lyon;Department of Emergency Psychiatry, Edouard Herriot Hospital;Nantes Université, Performance (MIP), University of Nantes

关键词: major depressive disorder;    venlafaxine;    rTMS;    patient-reported outcome;    BDI;    personality disorder;    suicide attempt;   

DOI  :  10.3389/fpsyg.2021.631614

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD). Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory (BDI 13 ). Associations between depression changes on BDI 13 domains (Negative Self-Reference, Sad Mood, and Performance Impairment), treatment arm, time, and clinical variables were tested in a mixed linear model. Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI 13 were personality disorders (+2.1 points), a past history of suicide attempt(s) (+1.7 points), age under 65 years old (+1.5 points), and female sex (+1.1 points). Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt(s).

【 授权许可】

CC BY