Neuroinflammation, Pain and Depression: An Overview of the Main Findings

Frontiers in Psychology

article

Ana Carolina Pinheiro Campos¹  Geiza Fernanda Antunes¹  Marcio Matsumoto²  Rosana Lima Pagano¹  Raquel Chacon Ruiz Martinez¹ 

[1] Division of Neuroscience, Hospital Sirio-Libanes;Anesthesiology Medical Center, Hospital Sirio-Libanes;Institute of Psychiatry, University of São Paulo School of Medicine

关键词: neuroinflammation;    pain;    depression;    depression-pain syndrome;    glial cells;   

DOI  :  10.3389/fpsyg.2020.01825

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Chronic pain is a serious public health problem with a strong affective-motivational component that makes it difficult to treat. Most patients with chronic pain suffer from severe depression; hence, both conditions coexist and exacerbate one another. Brain inflammatory mediators are critical for maintaining depression-pain syndrome and could be substrates for it. The goal of our paper was to review clinical and preclinical findings to identify the neuroinflammatory profile associated with the cooccurrence of pain and depression. In addition, we aimed to explore the regulatory effect of neuronal reorganization on the inflammatory response in pain and depression. We conducted a quantitative review supplemented by manual screening. Our results revealed inflammatory signatures in different preclinical models and clinical articles regarding depression-pain syndrome. We also identified that improvements in depressive symptoms and amelioration of pain can be modulated through direct targeting of inflammatory mediators, such as cytokines and molecular inhibitors of the inflammatory cascade. Additionally, therapeutic targets that improve and regulate the synaptic environment and its neurotransmitters may act as anti-inflammatory compounds, reducing local damage-associated molecular patterns and inhibiting the activation of immune and glial cells. Taken together, our data will help to better elucidate the neuroinflammatory profile in pain and depression and may help to identify pharmacological targets for effective management of depression-pain syndrome.

【 授权许可】

CC BY