A Possible Association Between Executive Dysfunction and Frailty in Patients With Neurocognitive Disorders

Frontiers in Psychology

article

Massimo Bartoli¹  Sara Palermo¹  Giuseppina Elena Cipriani¹  Martina Amanzio¹ 

[1] Department of Psychology, University of Turin;European Innovation Partnership on Active and Healthy Ageing

关键词: frailty;    mild cognitive impairment;    neurocognitive disorders;    Alzheimer’s disease;    Parkinson’s disease;    executive functions;    mini-review;   

DOI  :  10.3389/fpsyg.2020.554307

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Frailty is an age-related dynamic status, characterized by a reduced resistance to stressors due to the cumulative decline of multiple physiological systems. Several researches have highlighted a relationship between physical frailty and cognitive decline; however, the role of specific cognitive domains has not been deeply clarified yet. Current studies have hypothesized that physical frailty and neuropsychological deficits may share systemic inflammation and increased oxidative stress in different neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. However, the role of the executive dysfunction should be investigated in a more detailed way using a multidimensional approach. With this aim, we conducted a review of the literature on the few experimental articles published to discuss the existence of a relationship between frailty and cognitive impairment in neurocognitive disorders, particularly focusing on the domain of executive dysfunction. The data suggest that physical frailty and cognitive decline, especially executive dysfunction, are two aspects strongly linked in mild and major neurocognitive disorders due to Alzheimer’s and Parkinson’s disease. In light of this, a new framework linking aging, cognitive decline, and neurodegenerative diseases is needed. In order to analyze the effects that aging processes have on neural decline and neurocognitive disease, and to identify relevant groups of users and patients, future longitudinal studies should adopt a multidimensional approach, in the field of primary prevention and in the continuum from mild to major neurocognitive disorder.

【 授权许可】

CC BY