Effects of Electroconvulsive Therapy on Depression and Its Potential Mechanism

Frontiers in Psychology

article

Ming Li¹  Ranji Cui¹  Lihong Zhao¹  Wenbo Xu¹  Haisheng Zhao¹  Fangyi Zhao¹  Xiaohan Zou¹  Ziqian Cheng¹  Bingjin Li¹  Wei Yang¹ 

[1] Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University

关键词: depression;    ECT;    neuroplasticity;    Homer1a;    cognition;   

DOI  :  10.3389/fpsyg.2020.00080

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Depression is one of the most common disorders causing mortality around the world. Although electroconvulsive therapy (ECT) is, along with antidepressants and psychotherapy, one of the three major treatments of depression, it is still considered as the last resort for depressed patients. This situation is partially due to limited studies and uncertainty regarding its mechanism. However, decades of increased research have focused on the effects of ECT on depression and its potential mechanism. Furthermore, these investigations may suggest that ECT should be a first-line therapy for depression due to its profound effects in relieving desperation in certain situations. Here, we outline recent clinical and preclinical studies and summarize the advantages and disadvantages of ECT. Thus, this review may provide some hints for clinical application.

【 授权许可】

CC BY