Decreased Risk in the Pancreatic Cancer With History of Hay Fever: A Meta-Analysis

Frontiers in Public Health

article

Guannan Wang¹  Zhiwei Xu²  Jie Zhu³  Jiayu Ren⁴  Mina Chen⁵  Guijuan He⁶  Beibei Yu⁷ 

[1] Blood Purification Center, Ningbo Medical Center, Lihuili Hospital;Department of Critical Care Medicine, Ningbo Medical Center, Lihuili Hospital;Department of Hepato-Biliary-Pancreatic Surgery, Ningbo Medical Center, Lihuili Hospital;Department of Cardiology, Ningbo Medical Center, Lihuili Hospital;Department of Endocrinology and Respiratory Medicine, Ningbo Medical Center, Lihuili Hospital;School of Nursing, Zhejiang Chinese Medical University;The Affiliated Xiangshan Hospital of Wenzhou Medical University

关键词: pancreatic cancer;    allergy;    immune surveillance;    hay fever;    meta-analysis;   

DOI  :  10.3389/fpubh.2020.551490

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: An increasing incidence of pancreatic cancer has been observed worldwide over the last few decades. Previous reports suggested that hay fever, a common allergic disease, may function in pancreatic cancer. Data on hay fever as a risk or protective factor for pancreatic cancer was controversial in several case–control reports. So, we here did a meta-analysis on published studies to evaluate the association of hay fever and the risk of pancreatic cancer. Methods: A comprehensive literature search was performed through public databases. The association between hay fever and pancreatic cancer was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). The Cochran's Q test and I 2 index were used to evaluate heterogeneity. Results: We included 8 population-based case–control studies involving 10,454 participants from 1986 to 2014. A history of hay fever was associated with a decreased risk of pancreatic cancer (OR, 0.57; 95% CI, 0.50–0.64, P < 0.00001) through fixed effect model. Conclusion: The result of our study suggested that hay fever may significantly decrease the risk of pancreatic cancer.

【 授权许可】

CC BY