Zoledronic Acid in Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Kyphoplasty: A Meta-Analysis

Frontiers in Surgery

article

Peng Tian¹  Yue Liu²  Zhi-jun Li³  Gui-jun Xu⁴  Xin-long Ma¹ 

[1] Department of Traumatic Orthopedics, Tianjin Hospital;Department of Spine Surgery, Tianjin Hospital;Department of Orthopedics, Tianjin Medical University General Hospital;Department of Orthopaedics, Tianjin Hospital

关键词: zoledronic acid;    osteoporosis;    vertebral compression fractures;    percutaneous kyphoplasty;    meta-analysis;   

DOI  :  10.3389/fsurg.2021.668551

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs). Methods: Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1. Results: Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone. Conclusions: Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.

【 授权许可】

CC BY