Frontiers in Surgery | |
Zoledronic Acid in Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Kyphoplasty: A Meta-Analysis | |
article | |
Peng Tian1  Yue Liu2  Zhi-jun Li3  Gui-jun Xu4  Xin-long Ma1  | |
[1] Department of Traumatic Orthopedics, Tianjin Hospital;Department of Spine Surgery, Tianjin Hospital;Department of Orthopedics, Tianjin Medical University General Hospital;Department of Orthopaedics, Tianjin Hospital | |
关键词: zoledronic acid; osteoporosis; vertebral compression fractures; percutaneous kyphoplasty; meta-analysis; | |
DOI : 10.3389/fsurg.2021.668551 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Background: We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs). Methods: Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1. Results: Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone. Conclusions: Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.
【 授权许可】
CC BY
【 预 览 】
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