Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery

Frontiers in Surgery

article

Pablo A. Valdes¹  Parikshit Juvekar¹  Nathalie Y. R. Agar¹  Sylvain Gioux²  Alexandra J. Golby¹ 

[1] Department of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, United States;ICube Laboratory, University of Strasbourg

关键词: fluorescence-guided surgery;    quantitative fluorescence imaging;    protoporphyrin IX;    tissue optical properties;    brain tumors;   

DOI  :  10.3389/fsurg.2019.00031

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Fluorescence guided surgery (FGS) has fueled the development of novel technologies aimed at maximizing the utility of fluorescence imaging to help clinicians diagnose and in certain cases treat diseases across a breadth of disciplines such as dermatology, gynecology, oncology, ophthalmology, and neurosurgery. In neurosurgery, the goal of FGS technologies is to provide the neurosurgeon with additional information which can serve as a visual aid to better identify tumor tissue and associated margins. Yet, current clinical FGS technologies are qualitative in nature, limiting the ability to make accurate, reliable, and repeatable measurements. To this end, developments in fluorescence quantification are needed to overcome current limitations of FGS. Here we present an overview of the recent developments in quantitative fluorescence guidance technologies and conclude with the most recent developments aimed at wide-field quantitative fluorescence imaging approaches in neurosurgery.

【 授权许可】

CC BY