Redox control in the pathophysiology of influenza virus infection

BMC Microbiology

article

Chen, Ker-Kong¹  Yokoyama, Kazunari K.³  Minakuchi, Moeko³  Wuputra, Kenly⁴  Ku, Chia-Chen⁴  Pan, Jia-Bin⁴  Kuo, Kung-Kai⁷  Lin, Ying-Chu¹  Saito, Shigeo³  Lin, Chang-Shen⁴ 

[1] School of Dentistry, Kaohsiung Medical University;Department of Densitory, Kaohisung University Hospital;Waseda Research Institute for Science and Engineering, Waseca University;Graduate Institute of Medicine, Kaohsiung Medical University;Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University;Cell Therapy and Research Center, Kaohsiung Medical University Hospital;Department Surgery, Kaohsiung Medical University Hospital;Saito Laboratory of Cell Technology Institute;Department of Biological Sciences, National Sun Yat-sen University

关键词: Antioxidation;    Aryl hydrocarbon receptor;    Cellular oxidation;    Nuclear factor E2-related factor 2;    Reactive oxygen species;   

DOI  :  10.1186/s12866-020-01890-9

学科分类：放射科、核医学、医学影像

来源: BioMed Central

【 摘 要 】

Triggered in response to external and internal ligands in cells and animals, redox homeostasis is transmitted via signal molecules involved in defense redox mechanisms through networks of cell proliferation, differentiation, intracellular detoxification, bacterial infection, and immune reactions. Cellular oxidation is not necessarily harmful per se, but its effects depend on the balance between the peroxidation and antioxidation cascades, which can vary according to the stimulus and serve to maintain oxygen homeostasis. The reactive oxygen species (ROS) that are generated during influenza virus (IV) infection have critical effects on both the virus and host cells. In this review, we outline the link between viral infection and redox control using IV infection as an example. We discuss the current state of knowledge on the molecular relationship between cellular oxidation mediated by ROS accumulation and the diversity of IV infection. We also summarize the potential anti-IV agents available currently that act by targeting redox biology/pathophysiology.

【 授权许可】

CC BY|CC0