Chalcones-Sulphonamide Hybrids: Synthesis, Characterization and Anticancer Evaluation

Journal of the Korean Chemical Society

article

Mahammadali Khanusiya¹  Zakirhusen Gadhawala¹ 

[1] Department of Chemistry, The HNSB Ltd Science College

关键词: Chalcones-sulphonamide hybrid;    Anticancer;    Cell Lines;    Cytotoxicity;   

DOI  :  10.5012/jkcs.2019.63.2.85

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A panel of chalcone-sulphonamide hybrids has been designed by tethering appropriate sulphonamide scaffold with substituted chalcones as a multi-target drug for anticancer screening. Chalcones were prepared by Claisen-Schmidt condensation reaction of a substituted aldehyde with para aminoacetophenone. All the synthesized compounds were evaluated against selected five cancer cell lines, MCF-7 (Breast cancer), DU-145 (Human prostate Carcinoma), HCT-15 (Colon cancer), NCIH-522 (stage 2, adenocarcinoma; non-small cell lung cancer) and HT-3 (Human cervical cancer). Most of the synthesized chalcone-sulphonamide hybrids showed amended cytotoxic activity against various cancer cell lines which may be attributed to the linkage of sulphonamide with chalcone skeleton. The synthesized compounds were characterized by FT-IR, 1 H NMR, 13C NMR and HR-LCMS and spectral study assert the structures of synthesized sulphonamide-chalcone hybrids.

【 授权许可】

Unknown