Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice

The Journal of Veterinary Medical Science

article

Hiroto KOBAYASHI¹  Susumu IWAIDE¹  Naoki UJIKE¹  Tomoaki MURAKAMI¹ 

[1] Laboratory of Veterinary Toxicology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology

关键词: AA amyloidosis;    gastrointestinal disorder;    mouse;    oral transmission;    oxazolone;   

DOI  :  10.1292/jvms.21-0022

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and is reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastrointestinal disorder groups developed more severe amyloid deposition in systemic tissues than the group without gastrointestinal disorders. The results of this study suggest that gastrointestinal damage promotes the oral transmission of AA amyloidosis.

【 授权许可】

Unknown