Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells

The Journal of Veterinary Medical Science

article

Celina Emiko OKAMOTO-OKUBO¹  Fernanda da CRUZ LANDIM¹  Stelio Pacca Loureiro LUNA¹  Renata Navarro CASSU²  Jean Guilherme Fernandes JOAQUIM¹  Luciane dos REIS MESQUITA¹  Sheila Canevese RAHAL¹  Hugo S Salvador OLIVEIRA¹  Regina TAKAHIRA¹  Isadora ARRUDA¹  Leandro MAIA¹ 

[1] Department of Veterinary Surgery and Animal Reproduction, Department of Veterinary Clinics, São Paulo State University (Unesp), School of Veterinary Medicine and Animal Science;Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary Medicine, Universidade do Oeste Paulista

关键词: canine;    hip dysplasia;    mesenchymal stem cells;    osteoarthritis;    platelet-rich plasma;   

DOI  :  10.1292/jvms.20-0730

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

This prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests ( P <0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% ( P =0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively ( P =0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups ( P =0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment.

【 授权许可】

Unknown