Klein’s Remdesivir-Nucleobase Synthesis Revisited: Chemoselective Cyanation of Pyrrol-2-carboxaldehyde

Journal of the Brazilian Chemical Society

article

Santos, Juliana A. dos¹  Pereira, Vinícius R. D.¹  Silva, Adilson D. da¹  Amarante, Giovanni W.¹ 

[1] Departamento de Química, Universidade Federal de Juiz de Fora, Campus Martelos

关键词: remdesivir’s nucleobase;    triazine;    monochloramine;    Klein’s route;   

DOI  :  10.21577/0103-5053.20210037

学科分类：内科医学

来源: SciELO

【 摘 要 】

4-Aminopyrrolo[2,1- f ][1,2,4]triazine is a fundamental raw material in the synthesis of remdesivir, which demand has increased due to the tests and potential repositioning of this drug against Coronavirus disease 2019 (COVID-19). Here, three chemical steps route for the preparation of remdesivir’s nucleobase is described. Particularly, a highly chemoselective cyanation of Klein’s route and successful application of monochloramine prepared from commercial bleach as an N -amination reagent are presented.

【 授权许可】

CC BY