Oncogenic and tumor suppressor function of MEIS and associated factors

Turkish journal of biology

article

BİRKAN GİRGİN¹  MEDİNE KARADAĞ ALPASLAN³  FATİH KOCABA޹ 

[1] Regenerative Biology Research Laboratory, Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University;Graduate School of Natural and Applied Sciences, Yeditepe University;Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayıs University;Meinox Pharma Technologies

关键词: MEIS;    cancer;    small molecules;    MEIS inhibitors;   

DOI  :  10.3906/biy-2006-25

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in tumorigenesis are discussed with recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEIS inhibitors.

【 授权许可】

Unknown