E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells

Turkish journal of biology

article

ESRA AYDEMİR ÇOBAN¹  DİDEM TECİMEL¹  EZGİ KAŞIKCI¹  ÖMER FARUK BAYRAK¹  FİKRETTİN ŞAHİN¹ 

[1] Department of Genetics and Bioengineering, Engineering Faculty, Yeditepe University;Department of Medical Genetics, Faculty of Medicine, Yeditepe University, Yeditepe University Hospital;Department of Microbiology & Immunology, Albert Einstein College of Medicine

关键词: Panc-1;    AsPC1;    E-cadherin;    CRISPR/dCas9 activation;    pancreas cancer;   

DOI  :  10.3906/biy-1912-60

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.

【 授权许可】

Unknown