Astragalus membranaceus and Punica granatum alleviate infertility and kidney dysfunction induced by aging in male rats

Turkish journal of biology

article

AMEERA ALSHINNAWY¹  WAEL ELSAYED²  ALSHAIMAA TAHA¹  AHMED SAYED¹  AHMED SALEM² 

[1] Department of Biochemistry, Faculty of Science, Ain Shams University;Department of Zoology, Faculty of Science, Ain Shams University;Children’s Cancer Hospital

关键词: Infertility;    FSH;    LH;    testosterone;    sperm analysis;    kidney dysfunction;   

DOI  :  10.3906/biy-2001-5

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

By aging, male fertility and kidney function decline. Therefore, the investigation of health span-extending agents becomes more urgent to overcome aging-induced infertility and kidney dysfunction. The current research was undertaken to investigate the antiaging efficacy of Astragalus membranaceus telomerase activator-65 (Ta-65) and pomegranate supplements. Forty male Wistar rats were divided into young rats, aged rats, aged rats treated with Ta-65 (500mg/kg/day), and aged rats treated with pomegranate (250mg/kg/day). Testosterone, FSH, LH, and kidney functions were measured in serum. Sperm analysis as well as testicular histological examination was performed. Aging caused an imbalance in male sex hormones resulting in sperm abnormality and reductions in the sperm count and motility. Elevations in serum creatinine, uric acid, sodium, and potassium were reported in aged rats. Treatment with Ta-65 or pomegranate effectively ameliorated all the deteriorations induced by normal aging in male fertility and renal function. Ta-65 and pomegranate possessed strong antiaging activity by alleviating aging-induced male infertility through reestablishing the hormonal balance and testis architecture. They also alleviated the kidney dysfunction. On comparing Ta-65 with pomegranate, the improvement in FSH, LH, and sperm abnormalities caused by Ta-65 was much better than that caused by pomegranate.

【 授权许可】

Unknown