An insight into the epitope-based peptide vaccine design strategy and studies against COVID-19

Turkish journal of biology

article

MURAT TOPUZOĞULLARI¹  TAYFUN ACAR¹  PELİN PELİT ARAYICI¹  BURCU UÇAR¹  ERENNUR UĞUREL¹  EMRAH ŞEFİK ABAMOR¹  TÜLİN ARASOĞLU²  DİLEK BALIK¹  SERAP DERMAN¹ 

[1] Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University;Department of Molecular Biology and Genetics, Faculty of Arts and Science, Yıldız Technical University

关键词: SARS-CoV-2;    COVID-19;    epitope-based peptide vaccine design;    adjuvant;    immunoinformatics;   

DOI  :  10.3906/biy-2006-1

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020. It is crucial to design and produce an effective vaccine for the prevention of rapid transmission and possible deaths wcaused by the disease. Although intensive work and research are being carried out all over the world to develop a vaccine, an effective and approved formulation that can prevent the infection and limit the outbreak has not been announced yet. Among all types of vaccines, epitope-based peptide vaccines outshine with their low-cost production, easy modification in the structure, and safety. In this review, vaccine studies against COVID-19 have been summarized and detailed information about the epitope-based peptide vaccines against COVID-19 has been provided. We have not only compared the peptide vaccine with other types of vaccines but also presented comprehensive literature information about development steps for an effective and protective formulation to give an insight into on-going peptide vaccine studies against SARS-CoV-2.

【 授权许可】

Unknown