Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey

Turkish journal of biology

article

AYŞE BANU DEMİR¹  DOMENICO BENVENUTO²  YUSUF HAKAN ABACIOĞLU³  SILVIA ANGELETTI⁴  MASSIMO CICCOZZI² 

[1] Department of Medical Biology, Faculty of Medicine, İzmir University of Economics;Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome;Department of Medical Microbiology, Faculty of Medicine, İzmir University of Economics;Unit of Clinical LaboratoryScience, University CampusBio-Medico of Rome

关键词: SARS-CoV-2;    evolution;    mutation;    COVID-19;   

DOI  :  10.3906/biy-2005-69

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause coronavirus disease 2019 (COVID-19) pandemic. The first case of COVID-19 in Turkey has been declared in March 11th, 2020 and from there on, more than 150,000 people in the country have been diagnosed with the disease. In this study, 62 viral sequences from Turkey, which have been uploaded to GISAID database, were analyzed by means of their nucleotide substitutions in comparison to the reference SARS-CoV-2 genome from Wuhan. Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral strains from Europe, Oceania, North America and Asia. When the mutations were evaluated, C3037T, C14408T and A23403G were found to be the most common nucleotide substitutions among the viral isolates in Turkey, which are mostly seen as linked mutations and are part of a haplotype observed high in Europe.

【 授权许可】

Unknown