Abnormally Low Hemoglobin A1c as Harbinger of Hemoglobinopathy

Journal of the American Board of Family Medicine: JABFM

article

Joshua St. Louis¹  Anthony Valdini² 

[1] From the Department of Family Medicine, Tufts University School of Medicine;Department of Family Medicine, University of Massachusetts School of Medicine

关键词: Diabetes Mellitus;    Fetal Hemoglobin;    Glucose;    Glycated Hemoglobin A;    Hematology;    Hemoglobinopathies;    Primary Care Physicians;    Primary Health Care;   

DOI  :  10.3122/jabfm.2019.06.190124

学科分类：过敏症与临床免疫学

来源: The American Board of Family Medicine

【 摘 要 】

Hemoglobin A1c is frequently used in primary care to screen for and monitor disorders of glucose metabolism. A number of clinical syndromes may impact the accuracy of this laboratory value. This report describes a case of abnormally low hemoglobin A1c that was the result of an asymptomatic compound hemoglobinopathy (homozygous hemoglobin S disease and hereditary persistence of fetal hemoglobin) that had gone previously undiagnosed. Primary care physicians must be aware of such pitfalls in the use of this laboratory value and be prepared to use other values to monitor for and assess disorders of glucose metabolism.

【 授权许可】

CC BY