Desquamative interstitial pneumonia: still orphan and not always benign

European respiratory review

article

Vincent Cottin¹ 

[1] National Reference Centre for Rare Pulmonary Diseases, Louis Pradel Hospital, Claude Bernard University Lyon 1

DOI  :  10.1183/16000617.0183-2020

学科分类：工程和技术（综合）

来源: European Respiratory Society

【 摘 要 】

Desquamative interstitial pneumonia (DIP) was originally described by LIEBOW et al. [1] in 1965, and so named because of the observation of cells filling the alveolar spaces and the belief that this feature was due to desquamation of alveolar epithelial cells. It has since been recognised that the dominant histologic feature of DIP represents accumulation of intra-alveolar macrophages, and sometimes of giant cells [2]. Although the more accurate terminology of “alveolar macrophage pneumonia” has been proposed, the term DIP has persisted [3]. In the international classification of idiopathic interstitial pneumonias [3], DIP and respiratory bronchiolitis-interstitial lung disease (RB-ILD) belong to the group of smoking-related interstitial pneumonia, together with pulmonary Langerhans cell granulomatosis. Depending on the classification, combined pulmonary fibrosis and emphysema, smoking-related acute interstitial pneumonia, smoking-related interstitial fibrosis, rheumatoid arthritis-associated ILD, and idiopathic pulmonary fibrosis may also be considered as smoking-related ILDs [4, 5].

【 授权许可】

CC BY-NC