Magnetic Resonance Imaging-Based Screening for Asymptomatic Brain Tumors: A Review

The oncologist

article

Alfred I. Neugut¹  Paul Sackstein³  Grace C. Hillyer²  Judith S. Jacobson²  Jeffrey Bruce⁴  Andrew B. Lassman⁵  Philip A. Stieg⁶ 

[1] Department of Medicine, Columbia University;Department of Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University;Department of Epidemiology, Mailman School of Public Health, Columbia University;Department of Neurological Surgery, Columbia University;Department of Neurology, Columbia University;Department of Neurological Surgery, Weill-Cornell Medical College

关键词: Brain tumor;    Glioblastoma;    Screening;    Magnetic resonance imaging;    Asymptomatic;   

DOI  :  10.1634/theoncologist.2018-0177

学科分类：地质学

来源: AlphaMed Press Incorporated

【 摘 要 】

Brain tumors comprise 2% of all cancers but are disproportionately responsible for cancer-related deaths. The 5-year survival rate of glioblastoma, the most common form of malignant brain tumor, is only 4.7%, and the overall 5-year survival rate for any brain tumor is 34.4%. In light of the generally poor clinical outcomes associated with these malignancies, there has been interest in the concept of brain tumor screening through magnetic resonance imaging. Here, we will provide a general overview of the screening principles and brain tumor epidemiology, then highlight the major studies examining brain tumor prevalence in asymptomatic populations in order to assess the potential benefits and drawbacks of screening for brain tumors. Implications for Practice Magnetic resonance imaging (MRI) screening in healthy asymptomatic adults can detect both early gliomas and other benign central nervous system abnormalities. Further research is needed to determine whether MRI will improve overall morbidity and mortality for the screened populations and make screening a worthwhile endeavor.

【 授权许可】

CC BY|CC BY-NC