Feasibility and effectiveness of afatinib for poor performance status patients with EGFR-mutation-positive non-small-cell lung cancer: a retrospective cohort study

BMC Cancer

Chiao-En Wu¹  John Wen-Cheng Chang¹  Ching-Fu Chang¹  Chen-Yang Huang¹  Cheng-Ta Yang²  Chih-Hsi Scott Kuo²  Ping-Chih Hsu² 

[1]Department of Internal Medicine, Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, No. 5, Fu-Hsing Street, Kwei-Shan District, 333, Taoyuan City, Taiwan

[2]Department of Thoracic Medicine, Division of Thoracic Oncology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, No. 5, Fu-Hsing Street, Kwei-Shan District, 333, Taoyuan City, Taiwan

关键词: Lung cancer;    Afatinib;    EGFR;    TKI;    Performance status;   

DOI  :  10.1186/s12885-021-08587-w

来源: Springer

【 摘 要 】

BackgroundAfatinib is one of the standard treatments for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, data on the use of afatinib in patients with poor performance status (PS ≥ 2) are limited. This study aimed to retrospectively review the clinical outcomes and safety of afatinib treatment in EGFR-mutation-positive (EGFRm+) NSCLC patients with PS ≥ 2.MethodsThe data for 62 patients who were treated at Linkou Chang Gung Memorial Hospital from January 2010 to August 2019 were retrospectively reviewed. Patients’ clinicopathological features were obtained, and univariate and multivariate analyses were performed to identify possible prognostic factors. Data on adverse events were collected to evaluate general tolerance for afatinib therapy.ResultsUntil February 2020, the objective response rate, disease control rate, median progression-free survival (PFS), and overall survival (OS) were 58.1% (36/62), 69.4% (43/62), 8.8 months, and 12.9 months, respectively. The absence of liver metastasis (PFS: p = 0.044; OS: p = 0.061) and good disease control (p < 0.001 for PFS and OS) were independent favorable prognostic factors for PFS and OS. Bone metastasis (p = 0.036) and dose modification (reduction/interruption, p = 0.021) were predictors of disease control.ConclusionAfatinib demonstrated acceptable efficacy and safety in the current cohort. This study provided evidence to support the use of afatinib as a first-line treatment in EGFRm+ NSCLC patients with poor PS.

【 授权许可】

CC BY