Preliminary results in anterior cervical discectomy and fusion with the uncovertebral joint fusion cage in a goat model

BMC Musculoskeletal Disorders

Ying Hong¹  Xin Rong²  Yi-Wei Shen²  Ting-Kui Wu²  Bei-Yu Wang²  Yang Meng²  Lin Chen²  Ling-Yun Hu²  Yi Yang²  Hao Liu²  Li-Tai Ma²  Chen Ding² 

[1] Department of Operation Room and Anesthesia Center, West China Hospital, Sichuan University, No. 37 Guo Xue Rd, 610041, Chengdu, China;Department of Orthopedic surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Rd, 610041, Chengdu, China;

关键词: Luschka joints;    Uncovertebral joint fusion;    Cages;    Cervical spine;    Goats;    ACDF;   

DOI  :  10.1186/s12891-021-04412-4

来源: Springer

【 摘 要 】

ObjectiveTo preliminarily evaluate the safety and efficacy of the uncovertebral joint fusion cage in a goat model of cervical spine interbody fusion.MethodsTwenty-four healthy adult goats were randomly assigned to one of the two following groups: Group A, goats were implanted with an uncovertebral joint fusion cage combined with a local autograft and Group B, goats were implanted with a non-profile cage filled with a local autograft. The goats were prospectively evaluated for 24 weeks and then were sacrificed for evaluation. X-rays, CT and micro-CT scanning, and undecalcified bone histological analysis were used for the evaluation of fusion.Results75.0% (9/12) of the goats in Group A were evaluated as having fusion at 12 weeks, compared to 41.7% (5/12) in Group B. 83.3% (10/12) of the goats in Group A were evaluated as having fusion at 24 weeks compared to 58.3% (7/12) in Group B. The fusion grading scores in Group A were significantly higher than that in Group B both at 12 weeks and 24 weeks (P < 0.05). Micro-CT scanning and undecalcified bone histological analysis showed that new bone formation can be obviously found in the bilateral uncovertebral joint. The bone volume fraction (BV/ TV) in Group A (23.59 ± 4.43%) was significantly higher than Group B (16.16 ± 4.21%), with P < 0.05.ConclusionsPreliminary results of this study demonstrated that uncovertebral joint fusion cage is effective for achieving early bone formation and fusion without increase of serious complications.

【 授权许可】

CC BY