Gold standard for nutrition: a review of human milk oligosaccharide and its effects on infant gut microbiota

Microbial Cell Factories

Lingyun Zhou¹  Shunhao Zhang²  Caixia Pi²  Demao Zhang²  Tianle Li²  Jing Xie²  Wenbin Yang³ 

[1] Center of Infectious Diseases, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, 610041, Chengdu, China;State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China;State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, Department of Medical Affairs, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, South Renmin Road, 610041, Chengdu, Sichuan, China;

关键词: Human milk;    Human milk oligosaccharides (HMOs);    Oligosaccharides (OS);    Infant gut microbiota;    Bifidobacterium;    Prebiotics;    Infant formula;   

DOI  :  10.1186/s12934-021-01599-y

来源: Springer

【 摘 要 】

Human milk is the gold standard for nutrition of infant growth, whose nutritional value is mainly attributed to human milk oligosaccharides (HMOs). HMOs, the third most abundant component of human milk after lactose and lipids, are complex sugars with unique structural diversity which are indigestible by the infant. Acting as prebiotics, multiple beneficial functions of HMO are believed to be exerted through interactions with the gut microbiota either directly or indirectly, such as supporting beneficial bacteria growth, anti-pathogenic effects, and modulation of intestinal epithelial cell response. Recent studies have highlighted that HMOs can boost infants health and reduce disease risk, revealing potential of HMOs in food additive and therapeutics. The present paper discusses recent research in respect to the impact of HMO on the infant gut microbiome, with emphasis on the molecular basis of mechanism underlying beneficial effects of HMOs.

【 授权许可】

CC BY