Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [11C]PiB amyloid imaging

EJNMMI Physics

Dana L. Tudorascu¹  Ann D. Cohen¹  William E. Klunk¹  Howard J. Aizenstein²  Davneet S. Minhas³  Sarah K. Royse³  Charles M. Laymon⁴ 

[1] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA;Department of Bioengineering, University of Pittsburgh, PET Center, PUH B930, 200 Lothrop St, 15213, Pittsburgh, PA, USA;Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA;Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA;Department of Bioengineering, University of Pittsburgh, PET Center, PUH B930, 200 Lothrop St, 15213, Pittsburgh, PA, USA;

关键词: Nuclear imaging;    Brain;    Evaluation and performance;    Quantification and estimation;    Positron emission tomography;    Partial volume effect correction;   

DOI  :  10.1186/s40658-021-00403-5

来源: Springer

【 摘 要 】

PurposePartial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecification of scanner point-spread function (PSF) on GTM results in amyloid imaging, including the effect on amyloid status classification (positive or negative).MethodsTwenty-nine subjects with Pittsburgh Compound B ([11C]PiB) PET and structural T1 MR imaging were analyzed. FreeSurfer 5.3 (FS) was used to parcellate MR images into regions-of-interest (ROIs) that were used to extract radioactivity concentration values from the PET images. GTM PVC was performed using our “standard” PSF parameterization [3D Gaussian, full-width at half-maximum (w) of approximately 5 mm]. Additional GTM PVC was performed with “incorrect” parameterizations, taken around the correct value. The result is a set of regional activity values for each of the GTM applications. For each case, activity values from various ROIs were combined and normalized to produce standardized uptake value ratios (SUVRs) for nine standard [11C]PiB quantitation ROIs and a global region. GTM operating-point characteristics were determined from the slope of apparent SUVR versus w curves.ResultsErrors in specification of w on the order of 1 mm (3D) mainly produce only modest errors of up to a few percent. An exception was the anterior ventral striatum in which fractional errors of up to 0.29 per millimeter (3D) of error in w were observed.ConclusionWhile this study does not address all the issues regarding the quantitative strengths and weakness of GTM PVC, we find that with reasonable caution, the unavoidable inaccuracies associated with PSF specification do not preclude its use in amyloid quantitation.

【 授权许可】

CC BY