Low frequency conduction block: a promising new technique to advance bioelectronic medicines

Bioelectronic Medicine

Silvia V. Conde¹ 

[1] iNOVA4Health, CEDOC, NOVA Medical School, NMS, Faculdade Ciências Médicas, Universidade Nova de Lisboa, 1169-056, Lisboa, Portugal;CEDOC, Centro Estudos Doenças Crónicas, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Rua Câmara Pestana, nº6, 6A, Edifício CEDOC II, piso 3, 1150-082, Lisboa, Portugal;

关键词: low frequency alternating current;    reversibility;    efficacy;    onset response;    high frequency stimulation;   

DOI  :  10.1186/s42234-021-00073-9

来源: Springer

【 摘 要 】

Nerve conduction block is an appealing way to selective target the nervous system for treating pathological conditions. Several modalities were described in the past, with the kilohertz frequency stimulation generating an enormous interest and tested successfully in clinical settings. Some shortcomings associated with different modalities of nerve blocking can limit its clinical use, as the “onset response”, the high demand of energy supply, among others. A recent study by Muzquiz and colleagues describes the efficacy and reversibility of low frequency alternating currents in blocking the cervical vagus in the pig, in the absence of an onset effect and apparent lack of neuronal damage.

【 授权许可】

CC BY