Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine

Journal of Biological Engineering

Qingshu Li¹  Zhixiang Mu²  Huanan Wang³  Kaiwen Chen³  Shuai Yuan⁴  Ping Ji⁴  Tao Chen⁴ 

[1] Department of Pathology, Chongqing Medical University, 401147, Chongqing, P. R. China;Department of Periodontics, School and Hospital of Stomatology, Wenzhou Medical University, 325027, Wenzhou, Zhejiang, China;Key State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, No.2 Linggong Road, High-tech District, 116024, Dalian, P. R. China;Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, 401147, Chongqing, P. R. China;

关键词: I-PRF;    Ridge preservation;    Biomaterials;    Gelatin;    Dental implant;   

DOI  :  10.1186/s13036-021-00271-8

来源: Springer

【 摘 要 】

Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) as the potential candidate for extracted socket healing is introduced. The combination of GNPs and i-PRF not only possesses favorable mechanical properties to withstand external force but also accelerate the blood clotting time significantly. In addition, six beagle dogs were adopted to assess the angiogenic and osteogenic capacity of GNPs+i-PRF gel in vivo. The GNPs+i-PRF gel significantly produced the most blood vessels area, woven bone and low osteoclast activity in extracted sockets at 2 weeks postoperation and remarkably generated corticalization on the alveolar ridge crest at 8 weeks postoperation according to histological results. Therefore, GNPs+i-PRF gel can be recommended as the candidate grafting material regarding ridge preservation for its cost effectiveness, excellent biocompatibility, facilitation of blood clotting and favorable capacity of promoting angiogenesis and osteogenesis.

【 授权许可】

CC BY