Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers

World Journal of Surgical Oncology

Xiao Yu¹  Menggang Zhang¹  Wenzhi Guo¹  Yuting He¹ 

[1]Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, 450052, Zhengzhou, China

[2]Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China

[3]Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation At Henan Universities, 450052, Zhengzhou, China

[4]Henan Key Laboratory of Digestive Organ Transplantation, 450052, Zhengzhou, China

关键词: mC regulatory genes;    Frequent network mining;    Pan-cancer analysis;    Survival;    5-Methylcytosine;   

DOI  :  10.1186/s12957-021-02342-y

来源: Springer

【 摘 要 】

Background5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m5C regulators and the outcomes of modified nucleobases in RNAs.MethodsBased on The Cancer Genome Atlas (TCGA) database, we uncovered that mutations and copy number variations (CNVs) of m5C regulatory genes were significantly correlated across many cancer types. We then assessed the correlation between the expression of individual m5C regulators and the activity of related hallmark pathways of cancers.ResultsAfter validating m5C regulators’ expression based on their contributions to cancer development and progression, we observed their upregulation within tumor-specific processes. Notably, our research connected aberrant alterations to m5C regulatory genes with poor clinical outcomes among various tumors that may drive cancer pathogenesis and/or survival.ConclusionOur results offered strong evidence and clinical implications for the involvement of m5C regulators.

【 授权许可】

CC BY