LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC

Journal of Hematology & Oncology

Xinyi Qian¹  Bingjian Lu¹  Qiongzi Qiu¹  Yan Lu²  Chengxi Jiang³  Jia Li⁴  Liangliang Dong⁴  Juze Yang⁴  Xufan Li⁴  Enguo Chen⁵  Kejing Ying⁵  Pengyuan Liu⁶ 

[1] Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women’s Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China;Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women’s Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, China;Cancer Center, Zhejiang University, 310013, Hangzhou, Zhejiang, China;Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China;Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China;Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China;Cancer Center, Zhejiang University, 310013, Hangzhou, Zhejiang, China;Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China;Cancer Center, Zhejiang University, 310013, Hangzhou, Zhejiang, China;Department of Physiology and Center of Systems Molecular Medicine, Medical College of Wisconsin, 53226, Milwaukee, WI, USA;

关键词: LCAT3;    Lung cancer;    Long noncoding RNAs;    FUBP1;    MYC;    N6-methyladenosine;   

DOI  :  10.1186/s13045-021-01123-0

来源: Springer

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