Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study

BMC Oral Health

Mohammad Tariqur Rahman¹  Peter Mark Bartold²  Pit Hui Lew³  Syarida Hasnur Safii³  Rathna Devi Vaithilingam³  Nor Adinar Baharuddin³  Sargunan Sockalingam⁴  Noor Lide Abu Kassim⁵ 

[1] Dean’s Office, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia;Department of Dentistry, University of Adelaide, Adelaide, Australia;Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia;Department of Rheumatology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia;Kulliyyah of Education, International Islamic University Malaysia, 53100, Kuala Lumpur, Malaysia;

关键词: Anti-citrullinated protein antibodies (ACPA);    Citrullination;    Periodontitis;    Rheumatoid arthritis;   

DOI  :  10.1186/s12903-021-01712-y

来源: Springer

【 摘 要 】

BackgroundPrevious studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants.MethodsFull mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index, visual plaque index) was conducted and serum samples obtained from 80 participants comprising RA, Pd, both RA and Pd (RAPd) and healthy individuals (HC). Erythrocyte sedimentation rates (ESR) and periodontal inflamed surface area (PISA) were obtained. Serum samples were analysed for ACPA quantification using enzyme-linked immunosorbent assay (ELISA).ResultsMedian levels (IU/mL) of ACPA (interquartile range, IQR) in RAPd, RA, Pd and HC groups were 118.58(274.51), 102.02(252.89), 78.48(132.6) and 51.67(91.31) respectively. ACPA levels were significantly higher in RAPd and RA as compared to HC group (p < 0.05). However, ACPA levels of any of the groups were not correlated with any clinical periodontal and RA parameters within the respective groups.ConclusionsAt individual level, the amount of serum ACPA seem to have an increasing trend with the diseased condition in the order of RAPd > RA > Pd > HC. However, lack of any significant correlation between the serum ACPA levels with the clinical Pd and RA parameters warrants further studies to investigate the causal link between RA and Pd for such a trend. Further studies involving more inflammatory biomarkers might be useful to establish the causal link between Pd in the development and progression of RA or vice versa.

【 授权许可】

CC BY