Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

BMC Research Notes

Elisabeth Britten¹  Alexander Ziebart¹  Erik K. Hartmann¹  Robert Ruemmler¹  Rene Rissel¹  Moritz Gosling¹ 

[1] Department of Anesthesiology, Medical Centre of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany;

关键词: Extracellular histones;    ARDS;    Sepsis;    Porcine;    Lung damage;    Experimental;   

DOI  :  10.1186/s13104-021-05704-7

来源: Springer

【 摘 要 】

ObjectiveExtracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously.ResultsThe targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.

【 授权许可】

CC BY