CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Nanoscale Research Letters

Rongjun Zhang¹  Xiaoying Shi²  Jingfeng Liu³  Juan He³  Miaomiao Zhang³  Jian Chen³  Qingwen Wang³  Zheng Wang⁴ 

[1] Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, Guangdong, China;Cardiovascular Hospital, No. 1 Hospital of Xi’an City, 710002, Xi’an, China;Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, 518036, Shenzhen, Guangdong, China;Shenzhen Key Laboratory of Immunity and Inflammatory Diseases, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong, China;School of Advanced Materials and Nanotechnology, Xidian University, 710126, Xi’an, China;

关键词: Quantum Dots;    NSCLC;    Photodymatic therapy;    ROS;    PI3K/Akt;   

DOI  :  10.1186/s11671-021-03580-5

来源: Springer

【 摘 要 】

Non-small-cell lung cancer (NSCLC) has become the second most diagnosed malignant tumors worldwide. As our long-term interests in seeking nanomaterials to develop strategies of cancer therapies, we herein constructed novel CoFe2O4-quantum dots (QDs) with outstanding synergistic photothermal/photodynamic property which suppressed NSCLC efficiently without apparent toxicity. We showed that the combination of CoFe2O4-QDs + NIR treatment induces apoptosis of NSCLC cells. In addition, the CoFe2O4-QDs + NIR treatment also promotes reactive oxygen species generation to trigger cell death through regulating PI3K/AKT pathway. Moreover, the CoFe2O4-QDs + NIR treatment successfully eliminates tumor xenografts in vivo without apparent toxic effects. Taken together, we reported that the novel nanomaterials CoFe2O4-QDs could exhibit enhanced synergistic photothermal therapy and photodynamic therapy effect on killing NSCLC without toxicity, which could be a promising photosensitizer for NSCLC therapy.

【 授权许可】

CC BY