Patterns of immunotherapy-induced pneumonitis in patients with non-small-cell lung cancer: a case series

Journal of Medical Case Reports

Nisha Sikotra¹  Desiree Goh²  Sarah Picard²  Tim Clay³  Ashley Tan⁴  Eli Gabbay⁵ 

[1] Fiona Stanley Hospital, 11 Robin Warren D, 6150, Murdoch, WA, Australia;Sir Charles Gairdner Hospital, Hospital Ave, 6009, Nedlands, WA, Australia;St John of God Hospital, 12 Salvado Rd, 6008, Subiaco, WA, Australia;St John of God Hospital, 12 Salvado Rd, 6008, Subiaco, WA, Australia;Adjunct Associate Professor of Medicine, Edith Cowan University, Joondalup, WA, Australia;Bendat Family Respiratory Research and Development Fund, Subiaco, Australia;St John of God Hospital, 12 Salvado Rd, 6008, Subiaco, WA, Australia;Fiona Stanley Hospital, 11 Robin Warren D, 6150, Murdoch, WA, Australia;The University of Notre Dame, Fremantle, Australia;St John of God, Subiaco, Australia;

关键词: Pneumonitis;    Immunotherapy;    Malignancy;    NSCLC;    irAE;   

DOI  :  10.1186/s13256-021-02926-y

来源: Springer

【 摘 要 】

BackgroundImmunotherapy has become an efficacious option in the management of solid organ malignancies. Immune-related adverse events including pneumonitis are well described and may be particularly of concern in patients receiving immunotherapy for non-small-cell lung cancer.Case presentationsIn this paper, we describe three cases of immunotherapy-induced pneumonitis occurring in the management of lung malignancy. Our cases include a 54-year-old Caucasian woman with squamous cell lung cancer who was successfully rechallenged with immunotherapy after prior significant pneumonitis, a 65-year-old Caucasian man with metastatic squamous cell lung cancer who developed pneumonitis after multiple cycles of uneventful immunotherapy, and a 73-year-old Caucasian man with squamous cell lung cancer who developed early-onset pneumonitis with rebound on steroid taper.ConclusionsThis case series has provided further insight into the presentation and risk factors for pneumonitis in patients with non-small-cell lung cancer. Each of the cases of immunotherapy-induced pneumonitis illustrates the different potential patterns that may arise when immunotherapy-induced pneumonitis develops. This case series provides key learning points that may assist physicians managing non-small-cell lung cancer with immunotherapy.

【 授权许可】

CC BY