Objective assessment of impulse control disorder in patients with Parkinson’s disease using a low-cost LEGO-like EEG headset: a feasibility study

Journal of NeuroEngineering and Rehabilitation

Yueh-Sheng Chen¹  Wei-Che Lin²  Cheng-Hsien Lu³  Yung-Yee Chang³  Yih-Ru Wu⁴  Hsing-Yi Liang⁵  Yuan-Pin Lin⁶ 

[1] Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan;Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan;Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, No. 123, Dapi Road, Niaosong District, 833, Kaohsiung City, Taiwan;Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan;Department of Neurology, Linkou Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan;Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan;Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan;Department of Electrical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan;

关键词: Parkinson’s disease;    Impulse control disorders;    Electroencephalogram;    Event-related potential;    LEGO-like headset;   

DOI  :  10.1186/s12984-021-00897-1

来源: Springer

【 摘 要 】

BackgroundPatients with Parkinson’s disease (PD) can develop impulse control disorders (ICDs) while undergoing a pharmacological treatment for motor control dysfunctions with a dopamine agonist (DA). Conventional clinical interviews or questionnaires can be biased and may not accurately diagnose at the early stage. A wearable electroencephalogram (EEG)-sensing headset paired with an examination procedure can be a potential user-friendly method to explore ICD-related signatures that can detect its early signs and progression by reflecting brain activity.MethodsA stereotypical Go/NoGo test that targets impulse inhibition was performed on 59 individuals, including healthy controls, patients with PD, and patients with PD diagnosed by ICDs. We conducted two Go/NoGo sessions before and after the DA-pharmacological treatment for the PD and ICD groups. A low-cost LEGO-like EEG headset was used to record concurrent EEG signals. Then, we used the event-related potential (ERP) analytical framework to explore ICD-related EEG abnormalities after DA treatment.ResultsAfter the DA treatment, only the ICD-diagnosed PD patients made more behavioral errors and tended to exhibit the deterioration for the NoGo N2 and P3 peak amplitudes at fronto-central electrodes in contrast to the HC and PD groups. Particularly, the extent of the diminished NoGo-N2 amplitude was prone to be modulated by the ICD scores at Fz with marginal statistical significance (r = − 0.34, p = 0.07).ConclusionsThe low-cost LEGO-like EEG headset successfully captured ERP waveforms and objectively assessed ICD in patients with PD undergoing DA treatment. This objective neuro-evidence could provide complementary information to conventional clinical scales used to diagnose ICD adverse effects.

【 授权许可】

CC BY