Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

Stem Cell Research & Therapy

Taibing Fan¹  Minoru Ono²  Dehua Chang³  Yongqiang Jin⁴  Mingkui Zhang⁴  Shuang Gao⁵ 

[1] Children Heart Center, Fuwai Central China Cardiovascular Hospital, No.1 Fuwai Road, 450018, Zhengzhou, China;Department of Cardiac Surgery, The University of Tokyo Hospital, 7-3-1 Honggo, Bunkyo-ku, 113-8655, Tokyo, Japan;Department of Cell Therapy in Regenerative Medicine, The University of Tokyo Hospital, 7-3-1 Honggo, Bunkyo-ku, 113-8655, Tokyo, Japan;Heart Center, First Hospital of Tsinghua University, NO.6 JiuXianQiao 1st Road, 10016, Beijing, China;Research and Development Department, BOE Regenerative Medicine Technology Co., Ltd., NO.9 JiuXianQiao North Road, 100015, Beijing, China;

关键词: Cell sheet;    Cardiac tissue;    Cell therapy;    Mesenchymal stem cells;   

DOI  :  10.1186/s13287-021-02451-1

来源: Springer

【 摘 要 】

In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation functions. In combination with cell sheet technology, MSCs could be more easily transplanted to the ischemic area. The long-term retention of MSCs in the affected area was realized and significantly improved the curative effect. In this review, we summarized the research and the applications of MSC sheets to the treatment of ischemic heart tissue. At present, many types of MSCs have been considered as multipotent cells in the treatment of heart failure, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose-derived mesenchymal stem cells (AD-MSCs), umbilical cord-derived mesenchymal stem cells (UC-MSCs), and skeletal myoblasts (SMs). Since UC-MSCs have few human leukocyte antigen-II and major histocompatibility complex class I molecules, and are easy to isolate and culture, UC-MSC sheets have been proposed as a candidate for clinical applications to ischemic heart disease.

【 授权许可】

CC BY