Eosinophilic interstitial nephritis and cardiac insufficiency in Kimura’s disease: a case report

BMC Nephrology

Min Yang¹  Hua Liu¹  Li Xiang¹  Yan Yang¹  Min Li¹  Hua Zhou¹  Dachuan Zhang² 

[1] Department of Nephrology, The Third Affiliated Hospital of Soochow University, No. 185, Juqian Road, 213003, Changzhou, Jiangsu Province, China;Department of Pathology, The Third Affiliated Hospital of Soochow University, 213003, Changzhou, China;

关键词: Kimura’s disease;    Eosinophilic interstitial nephritis;    Cardiac insufficiency;   

DOI  :  10.1186/s12882-021-02454-3

来源: Springer

【 摘 要 】

BackgroundKimura’s disease (KD) is a rare chronic inflammatory disease and the etiology remains uncharacterized. The typical manifestations are painless lymph node or subcutaneous masses. There is currently no report of prominent renal interstitial injury and cardiac insufficiency in KD.Case presentationA 45-year-old man was referred to our hospital with dark urine, subcutaneous masses in forehead and right retroauricular, multiple lymphadenopathy and unexplained cardiac insufficiency. Renal biopsy demonstrated eosinophilic interstitial nephritis. Laboratory tests revealed eosinophilia and a high level of serum IgE. A biopsy of cervical lymph node was performed and KD was diagnosed. Treatment with oral prednisone resulted in a decrease of eosinophil, serum IgE, improvement of cardiac function, and regression of the subcutaneous mass.ConclusionsWe describe an extremely rare KD case presenting with eosinophilic interstitial nephritis, cardiac insufficiency and significant response to prednisone. The clinicians should improve the disease awareness and find optimal treatment.

【 授权许可】

CC BY