Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level

Cell & Bioscience

Bozhi Wang¹  Fen Ma¹  Siwei Zhang¹  Lianhao Song¹  Fengmin Zhang¹  Lanlan Wei² 

[1] Department of Microbiology, Harbin Medical University, 150081, Harbin, China;Wu Lien-Teh Institute, Harbin Medical University, 150081, Harbin, China;Department of Microbiology, Harbin Medical University, 150081, Harbin, China;Wu Lien-Teh Institute, Harbin Medical University, 150081, Harbin, China;Shenzhen Third People‘s Hospital, Second Hospital, Affiliated to Southern University of Science and Technology, 518112, Shenzhen, China;

关键词: Cell communication;    Ligand-receptor interactions;    Single cell RNA sequencing;    Target therapy;    Tumor microenvironment;   

DOI  :  10.1186/s13578-021-00635-z

来源: Springer

【 摘 要 】

BackgroundCellular communication is an essential feature of multicellular organisms. Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communication and intimately linked to many degeneration processes leading to diseases.Main bodyThis study reviewed the history of ligand-receptor and presents the databases which store ligand-receptor pairs. The recently applications and research tools of ligand-receptor interactions for cell communication at single cell level by using single cell RNA sequencing have been sorted out.ConclusionThe summary of the advantages and disadvantages of analysis tools will greatly help researchers analyze cell communication at the single cell level. Learning cell communication based on ligand-receptor interactions by single cell RNA sequencing gives way to developing new target drugs and personalizing treatment.

【 授权许可】

CC BY