Short-term effect of ovariohysterectomy on urine serotonin, cortisol, testosterone and progesterone in bitches

BMC Research Notes

Eva Hydbring-Sandberg¹  Andrzej Madej¹  Elin Larsson¹  Odd Viking Höglund² 

[1] Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, PO Box 7011, 750 07, Uppsala, Sweden;Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, 750 07, Uppsala, Sweden;

关键词: Bitches;    Canine;    Cortisol;    Gonadectomy;    Neuter;    Progesterone;    Serotonin;    Spay;    Testosterone;    Urinary hormones;   

DOI  :  10.1186/s13104-021-05680-y

来源: Springer

【 摘 要 】

ObjectiveThis study aimed to investigate the short-term effect of ovariohysterectomy on urine levels of serotonin and its relation to levels of cortisol, testosterone and progesterone in female dogs. Seven bitches were studied before surgical ovariohysterectomy and then once a week during 4 weeks. Spontaneously voided urine samples were collected and concentration ratios of hormone/creatinine in urine were analysed.ResultsThe bitches had significantly lower levels of cortisol, testosterone, and progesterone 1 week after ovariohysterectomy compared with before and the levels stayed low throughout the study (P ≤ 0.05). Interestingly, serotonin levels tended to increase 4 weeks after surgery (P = 0.08). A positive correlation between cortisol and progesterone was found before and after surgery. After surgery, serotonin was positively correlated with cortisol and progesterone (P ≤ 0.05).

【 授权许可】

CC BY