Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study

BMC Nephrology

Hui Zheng¹  Zhixiang Shen¹  Yang Cheng¹  Haifeng Xu²  Min Liu²  Yu Liu²  Xiaotian Chen³  Chong Shen⁴  Xiaojun Wu⁵ 

[1] Center for Health Management, Geriatric Hospital of Nanjing Medical University, 65 Jiangsu Road, 21009, Nanjing, China;Department of Chronic Non-communicable Diseases Control, Center for Disease Control and Prevention of Jurong City, 212400, Jurong, China;Department of Clinical Epidemiology, Children’s Hospital of Fudan University, 201102, Shanghai, China;Department of Epidemiology, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China;Division of Clinical Epidemiology, Geriatric Hospital of Nanjing Medical University, 210009, Nanjing, China;People’s Hospital of Jurong City, 212400, Jurong, China;

关键词: Handgrip strength;    chronic kidney disease;    Chinese community-dwelling persons;   

DOI  :  10.1186/s12882-021-02452-5

来源: Springer

【 摘 要 】

BackgroundPoor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigating.Methods From September to November 2015, we conducted a cross-sectional study consisting of 10,407 participants in Jurong City, China. Age-related and sex-specific HGS percentile curves were constructed using the GAMLSS method. In addition, logistic regression was applied to estimate the association between HGS and the presence of CKD with odds ratios (ORs) and 95 % confidence intervals (CIs).ResultsParticipants with low HGS tended to be older and were more likely to have CKD (8.73 %). Smoothed centile curves of HGS showed a similar shape in both sexes: participants peaked at approximately 20–35 years old and gradually decreased after the age of 50. In addition, independent of age and other factors, the decreased presence of CKD was significantly identified in individuals with moderate (OR: 0.64, 95 % CI: 0.49–0.83) and high HGS (OR: 0.37, 95 % CI: 0.23–0.58).ConclusionsWe concluded that HGS was significantly negatively associated with CKD in Chinese community-dwelling persons.

【 授权许可】

CC BY